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Sex-determining region Y protein - Wikipedia
Sex-determining region Y protein ( SRY ), or testis-determining factor ( TDF ), is a DNA-binding protein (also known as gene-regulatory protein/ transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals ( placental mammals and marsupials ). [5] .
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Correct regulation of SRY is critical: aberrant timing or level of Sry expression is known to disrupt testis development in mice and we hypothesize that mutations that affect regulation of human SRY may account for some of the many cases of XY gonadal dysgenesis that currently remain unexplained.
New insights into SRY regulation through identification of 5' conserved ...
A leading U.S. bank regulator said Tuesday that the government will be "open-minded" about making changes to a contentious plan to raise large bank capital requirements.
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The regulation of SRY is under tight control to ensure its expression at the right time, place and level necessary to initiate male sex determination. In mice, delayed onset of Sry expression, or reduced levels of Sry expression, is known to cause full or partial XY sex reversal [ 8 - 10 ].